Pomegranate’s anti-inflammatory effects strengthened
By Stephen Daniells, 10-Apr-2009
Related topics: Research, Antioxidants, carotenoids, Phytochemicals, plant extracts, Cardiovascular health, Diabetes

A polyphenol-rich pomegranate extract may reduce inflammation, and positively effect chronic disease risk, according to results of a new cell study from the US.



Findings published in the open access Journal of Inflammation suggest that a polyphenol-rich pomegranate fruit extract (POMx) acts by inhibiting the production of pro-inflammatory cytokines at a gene expression level.


“Our’s is the first report that shows POMx inhibits the inflammatory activity of activated human mast cells [known to play a central role in the inflammatory process] like KU812 cells,” wrote the researchers from the University of South Carolina and Case Western Reserve University.


“POMx or POMx-derived compounds may be of value for the treatment of inflammatory diseases in which mast cells play an active role,” they added.


If the study can be repeated in humans it offers promise for preventing chronic inflammation, brought about by an over-expression or lack of control of the normal protective mechanism. Chronic inflammation has been linked to range of conditions linked to heart disease, osteoporosis, cognitive decline and Alzheimer's, type-2 diabetes, and arthritis.


Pomegranate, a rich source of antioxidants, has been linked to improved heart health, but a growing body of science indicates the fruit protect against prostate cancer. Studies have also reported a role in joint health by slowing cartilage loss in arthritis.


It is these antioxidants, and particularly ellagitannin compounds like punicalagins and punicalins, which accounts for about half of the fruit's antioxidant ability, that are reportedly behind the proposed health benefits.